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合成了两个系列共8个哌嗪类衍生物，用红外、核磁、质谱及元素分析确证结构。经豚鼠离体心房正性肌力作用试验，所筛选的8个化合物中，有7个具有不同程度的活性。其中目标物Ⅱ与Ⅸ正性肌力作用均强于对照品氨力农及维司力农（vesnarinone），且（Ⅸ）与氨力农比较有显著性差异。
A total of eight piperazine derivatives were synthesized from two series. Their structures were confirmed by IR, NMR, MS and elemental analysis. In guinea pig atrial inotropic effect test, 8 of the selected compounds, 7 have varying degrees of activity. Among them, the positive inotropic effects of target Ⅱ and Ⅸ were stronger than that of the control ammonia and vesnarinone, and (Ⅸ) had significant difference with ammonia-benton.