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抵抗素最初被认为是联系肥胖、胰岛素抵抗和2型糖尿病的新型脂肪细胞因子。但随后的研究发现抵抗素在人体主要参与炎症和免疫反应。动脉粥样硬化是一种慢性炎症性过程,体外研究提示抵抗素可能参与动脉粥样硬化的发生发展。本文就抵抗素参与动脉粥样硬化的具体机制作一综述。
Resistin was first thought to be a new type of adipocytokine linked to obesity, insulin resistance and type 2 diabetes. However, subsequent studies found that resistin is mainly involved in inflammation and immune response in the human body. Atherosclerosis is a chronic inflammatory process, in vitro studies suggest that resistin may be involved in the development of atherosclerosis. This article summarizes the specific mechanism of resistin involved in atherosclerosis.