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目的:观察短期胰岛素强化治疗对2型糖尿病尿微量白蛋白的影响。方法:64例2型糖尿病合并早期糖尿病肾病患者随机分为胰岛素强化治疗组及常规治疗组各32例,观察两组治疗前后6个月空腹血糖、餐后2小时血糖、糖化血红蛋白A1c及尿白蛋白排泄率(urinealbuminexcretion,UAE)等指标的变化。结果:胰岛素强化治疗组治疗前后空腹血糖犤(8.6±3.3)、(6.0±1.4)mmol/L犦,餐后2小时血糖犤(12.2±4.8)、(8.8±3.1)mmol/L犦,糖化血红蛋白A1c犤(0.078±0.018)、(0.065±0.014)犦,UAE犤203、135mg/24h犦,比较均差异有统计学意义(P<0.01);且与常规治疗组治疗比较,亦有统计学意义;而常规治疗组各项指标治疗前、后比较差异均无统计学意义(P>0.05)。结论:胰岛素强化治疗能维持2型糖尿病良好的血糖水平,降低近期UAE。
Objective: To observe the effect of short-term intensive insulin therapy on type 2 diabetes mellitus. Methods: Sixty-four patients with type 2 diabetes mellitus and early diabetic nephropathy were randomly divided into insulin intensive treatment group and conventional treatment group, with 32 cases in each group. The fasting blood glucose, postprandial blood glucose, hemoglobin A1c and urinary albumin Protein excretion rate (urinealbuminexcretion, UAE) and other indicators of change. Results: The levels of fasting blood glucose (FBG) before and after intensive insulin therapy were (8.6 ± 3.3), (6.0 ± 1.4) mmol / L, 2 hours postprandial blood glucose 12.2 ± 4.8, (8.8 ± 3.1) mmol / Hemoglobin A1c 犤 (0.078 ± 0.018), (0.065 ± 0.014) 犦, UAE 犤 203,135mg / 24h 犦, the differences were statistically significant (P <0.01); and compared with the conventional treatment group, there are statistics However, there was no significant difference between the conventional treatment group before and after treatment (P> 0.05). CONCLUSIONS: Intensive insulin therapy maintains good blood glucose levels in type 2 diabetes and reduces recent UAE.