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目的 了解1983～1993年因输注同一批号的美国进口第Ⅷ因子导致HIV感染的4例血友病患者病程进展。方法 进行追踪观察。结果 发现最少注射剂量为955U,最多为2810U;均属HIV-1,B亚型,随病程发展,T4淋巴细胞明显下降,临床后期均有发热或腹泻,体重减轻30％以上,并出现各种机遇性感染,除1例因血友病复发1987年死于颅内出血,其余3例存活期分别为10,14,16年。结论 应加强血源管理;在营造一个宽松的社会环境使HIV感染者免受歧视的同时,也应教育感染者遵守国家法律,遵守社会公德;在艾滋病药价昂贵,疫苗尚未问世的现状下,健康教育仍是最经济最有效的良策。
Objective To understand the course of disease in 4 hemophiliacs from 1983 to 1993 in which HIV infection was caused by the same factor VIII in the United States. Methods to follow-up observation. The results showed that the minimum injection dose was 955U and the maximum was 2810U. All of them belonged to HIV-1 and B subtypes. With the development of the disease course, the T4 lymphocytes decreased obviously. All the patients had fever or diarrhea in the later period and the weight loss was over 30% Opportunistic infection, in addition to a case of recurrent hemophilia in 1987 died of intracranial hemorrhage, the remaining three cases were 10, 14, 16 years. Conclusions should be to strengthen blood management; to create a relaxed social environment so that HIV-infected persons from discrimination at the same time, should also be educated to comply with national laws and comply with national laws, social ethics; AIDS is expensive, the vaccine has not yet come out of the status quo, Health education is still the most economical and effective way.