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1目的 探讨胎盘型谷胱甘肽 S-转移酶 (GSTπ)在胃癌中表达的意义。 2方法 应用 L SAB免疫组化方法检测了胃癌及癌旁黏膜组织 GSTπ的表达。 3结果 正常胃黏膜组织 GSTπ阳性表达率为 16 .7% ,肠上皮化生和不典型增生腺体 GSTπ阳性表达率分别为 71.4%和 10 0 .0 % ,显著高于正常胃黏膜 (χ2 =8.4,19.4,P <0 .0 1)。胃癌组织中 GSTπ阳性表达率为 80 .3% ,高分化腺癌和低分化腺癌 GSTπ阳性表达率显著高于未分化癌和黏液腺癌 (χ2 =13.8,P<0 .0 1)。GSTπ表达与肿瘤大小、浸润深度及淋巴结转移等无关 (P>0 .0 5 )。4结论GSTπ可作为胃癌及其癌前病变的标志酶 ,对胃癌的早期诊断有辅助意义。
1 Objective To investigate the significance of placental glutathione S-transferase (GSTπ) expression in gastric cancer. 2 method using L SAB immunohistochemical detection of gastric cancer and adjacent mucosa tissue GSTπ expression. 3 Results The positive expression rate of GSTπ in normal gastric mucosa was 16.7%, the positive rates of GSTπ in intestinal metaplasia and atypical hyperplastic glands were 71.4% and 100.0%, respectively, which were significantly higher than those in normal gastric mucosa (χ2 = 8.4, 19.4, P <0.01). The positive expression rate of GSTπ in gastric cancer was 80.3%. The positive expression rate of GSTπ in well differentiated and poorly differentiated adenocarcinoma was significantly higher than that in undifferentiated carcinoma and mucinous adenocarcinoma (χ2 = 13.8, P <0.01). GSTπ expression was not related to tumor size, depth of invasion and lymph node metastasis (P> 0.05). 4 Conclusions GSTπ can be used as a marker of gastric cancer and its precancerous lesions, the early diagnosis of gastric cancer is of secondary significance.