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五十年代后期,在骨髓移植的实验研究基础上,开始了人的骨髓移植,并用于治疗放射事故病人、免疫缺损、再生障碍性贫血以及白血病等患者,特别是在孪生子之间的骨髓移植中取得了良好的疗效。但是,在同种骨髓移植中遇到了严重的、甚至是致死性的威胁,即移植物抗宿主(GVH)反应的发生可以导致骨髓移植的失败。这是六十年代临床骨髓移植治疗进入停滞状态的主要原因。Bortin总结了1967年以前的骨髓移植
In the late fifties, based on the experimental study of bone marrow transplantation, human bone marrow transplantation was started and used to treat patients with radiation accidents, immunodeficiency, aplastic anemia and leukemia, especially bone marrow transplantation between twins Has made a good effect. However, there is a serious, if not fatal, threat of allogeneic bone marrow transplantation, where graft-versus-host (GVH) responses can lead to failure of bone marrow transplantation. This is the main reason for the stagnation of clinical bone marrow transplantation in the 1960s. Bortin summarizes bone marrow transplants before 1967