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目的:探讨多种肿瘤标志物联合检测在消化道恶性肿瘤筛查、诊断中的应用价值。方法:选择我院在2010年2月-2015年2月间病理检查确诊的恶性消化道肿瘤患者100例作为联合组,另选择同时期100例良性肿瘤者血样作对照组,分别对上述两组病例进行静脉采血、多标志物检测,对比两组的恶性肿瘤阳性检出率、各单项标志物指标检测结果。结果:经比较,联合组的恶性肿瘤阳性检出率明显高于对照组(P<0.05),而与单项标志物相比,多项标志物联合检测的灵敏度更高(P<0.05)。结论:多种标志物联合检测对于消化道恶性肿瘤的筛查准确性较高,并能为各类消化道癌的临床诊断、病型鉴别提供重要参考,具有重要推广、应用价值。
Objective: To explore the value of combined detection of multiple tumor markers in the screening and diagnosis of gastrointestinal malignancies. Methods: One hundred patients with malignant gastrointestinal tumors confirmed by pathology in our hospital from February 2010 to February 2015 were selected as the combined group. Another 100 benign tumor blood samples from the same period were selected as the control group. The above two groups Venous blood samples were taken and multiple markers were detected. The positive detection rate of malignant tumors and the detection results of each single marker index were compared between the two groups. Results: The positive rate of malignant tumors in the combined group was significantly higher than that in the control group (P <0.05). However, the sensitivity of the combined detection of multiple markers was higher than that of the single marker (P <0.05). Conclusion: The combined detection of multiple markers is highly accurate for the screening of malignant tumors of the digestive tract and can provide important reference for the clinical diagnosis and type identification of various types of gastrointestinal cancers, and has important promotion and application value.