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两例患线状硬皮病的病人出现系统性红斑狼疮(SLE)。这种伴发以前仅有一例报告。高滴度的RNP抗体的存在导致混合结缔组织病的早期诊断。更严重的临床受累和Sm(病例一)或nDNA抗体的出现,帮助了SLE诊断的确定。系统性结缔组织病的鉴别诊断的这些研究的意义简要地加以讨论。局限性硬皮病病人抗RnP抗体的存在可能予示更严重的结缔组织病。
Two patients with scleroderma developed systemic lupus erythematosus (SLE). There was only one previous report of this companion. The presence of high titers of RNP antibodies leads to the early diagnosis of mixed connective tissue disease. More severe clinical involvement and the presence of Sm (case one) or nDNA antibodies helped to confirm the diagnosis of SLE. The significance of these studies in the differential diagnosis of systemic connective tissue disease is briefly discussed. The presence of anti-RnP antibodies in patients with localized scleroderma may indicate more severe connective tissue disease.