静注丙球通过激活二氢吡啶-ryanodine受体复合物可增加肌浆钙离子浓度

• 作 者: 魏芳
• 机 构: 济南军区生物制品药物研究所
• 出 处: 国外医学.输血及血液学分册
• 发表日期: 1999年01期
• 关键词: 丙球 ryanodine 受体复合物 钙离子浓度 释放反应 人骨骼肌细胞 二氢吡啶 原生质网 肌浆 乙酰胆碱受体

作者报导,静注丙球可使体外培养的人骨骼肌细胞从原生质网释放Ca~(2+),且这种释放作用与静注丙球剂量呈正相关。阻断二氢吡啶-ryanodine受体复合物可解除静注丙球介导的Ca~(2+)释放反应,但抑制Na~+通道或乙酰胆碱受体却不能阻止此种释放反应的发生。静注丙球的这种作用不是由它的主要成分Ig分子所介导的,加热可破坏这种作用,且不同厂家生产的静注丙球的这种作用也存在差异。有数据表明,在静注丙球制剂中

The authors report that intravenous infusion of coccus causes in vitro cultured human skeletal muscle cells to release Ca ~ (2+) from the cytoplasm, and this release is positively correlated with intravenous infusion of propofol. Blocking the dihydropyridine-ryanodine receptor complex can relieve the intravenous injection of Ca ~ (2 +) - mediated cDNF but inhibit the Na ~ + channel or acetylcholine receptor but can not prevent this release reaction. This effect of intravenous injection of coccidia is not mediated by its main component, Ig, and heating can disrupt this effect, and there are differences in the role of intravenous cicles produced by different manufacturers. Data show that in intravenous corticosteroid formulations