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高血压发病机理比较复杂,还有许多尚不了解的病因存在。本文将从免疫学角度,综述免疫与高血压的关系。一、遗传性自发性高血压大鼠自发性高血压大鼠(spontaneously hypertensive rats,简称SHR)是Okamoto和Aoki于1963年从血压正常的WKY株大鼠中通过近亲选择性交配的方式分离出来的。SHR出生后,血压逐渐上升,生后3～4个月高血压确立。SHR常伴发肾和心血管并发症,一般在生后24个月死亡。Aoki等发现,
Hypertension pathogenesis is more complicated, there are many still do not understand the existence of the cause. This article reviews the relationship between immunity and hypertension from an immunological perspective. First, spontaneous hypertensive rats (spontaneous hypertensive rats, spontaneously hypertensive rats, referred to as SHR) Okamoto and Aoki in 1963 from the normotensive WKY strain rats by selective mating of relatives isolated . SHR after birth, blood pressure gradually increased, 3 to 4 months after birth, hypertension established. SHR often associated with renal and cardiovascular complications, usually 24 months after birth died. Aoki found that,