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用单克隆抗体对83例初诊为急性白血病(急白)患儿的白血病细胞进行表面标记分析,发现9例形态学与免疫学分型诊断不一致,其中3例形态学诊断为ALL中,2例属于淋或T-髓系双表型急白,1例为极低分化型ANLL;形态学分类属于AUL的5例中,1例为AMKL,4例为AML,其中3例可能为定向于单核系的未分化型AML;形态学疑为肿瘤骨髓转移的1例,也证实是AML。作者认为细胞表面标记分析在小儿急白疑难病例的诊断中具有重要作用。
Monoclonal antibodies on 83 cases of newly diagnosed acute leukemia (acute white) in children with leukemia cells surface marker analysis found that 9 cases of morphology and immunological classification of diagnosis is inconsistent, of which 3 cases were diagnosed as ALL ALL morphology, 2 cases belong to Myeloid leukoplakia or T-myeloid leukoplakia, 1 case of very poorly differentiated ANLL; morphological classification of AUL in 5 cases, 1 case of AMKL, 4 cases of AML, of which 3 cases may be directed to the mononuclear Department of undifferentiated AML; morphological suspected bone tumor metastasis in 1 cases, also confirmed that AML. The authors believe that cell surface marker analysis plays an important role in the diagnosis of children with acute and difficult cases.