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本研究按照农药登记毒理学试验方法(GB15670－1995),对毒菌锡原药进行了大鼠急性经口毒性试验,蓄积性毒性试验,亚慢性(90天)混饲经口毒性试验,小鼠骨髓细胞微核率,小鼠睾丸初级精母细胞染色体畸变率试验,以及Ames试验和皮肤致敏试验.结果显示雌、雄大鼠急性经口毒性(LD50)分别为162、200mg／kg,蓄积系数≥1.亚慢性毒性试验结果显示最大无作用剂量为1．6mg／kg.小鼠骨髓细胞微核率,小鼠睾丸初级精母细胞染色体畸变率试验,以及Ames试验和皮肤致敏试验结果均为阴性.
According to the pesticide registration toxicology test method (GB15670-1995), this study carried out acute oral toxicity test, accumulative toxicity test and sub-chronic Micronucleus rate of rat bone marrow cells, chromosomal aberration rate of primary testicular spermatocytes in mice and Ames test and skin sensitization test.The results showed that the acute oral toxicity (LD50) of male and female rats were 162 and 200 mg / kg, respectively Coefficient of ≥ 1. Subchronic toxicity test results showed that the maximum non-effect dose of 1.6mg / kg mouse bone marrow micronucleus rate, mouse testicular primary spermatocyte chromosome aberration rate test, and Ames test and skin sensitization test results All negative.