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本文分析在用扎莫特罗(xamoterol)与安慰剂治疗的心衰患者中,使用卡托普利和依那普利对死亡率的影响。方法将10个国家66个中心的病例用双盲、随机法分为扎莫特罗组与安慰剂组,每例均用利尿药及一种血管紧张素转换酶抑制剂。所选病例的心功能为Ⅲ～Ⅳ级,左室功能不全必须具备下列标准之一:心胸比例>0.55;短轴缩短分数<20％(超声)或射血分数<35％(核素)。下列病例除外:急性心梗(病程<8周),主动脉瓣或肺动脉瓣狭窄,肥厚型心肌病及运动试验时间不能达1min者。根据记录及观察者的陈述判断死
This article analyzes the effect of captopril and enalapril on mortality in patients with heart failure treated with xamoterol and placebo. Methods A total of 66 centers in 10 countries were divided into two groups: ZAMODARO group and placebo group by double-blind randomization. Diuretics and an angiotensin converting enzyme inhibitor were used in each case. The cardiac function of the selected cases was grade III-IV. One of the following criteria must be met for left ventricular dysfunction: cardiothoracic ratio> 0.55; fractional shortening <20% (ultrasound) or ejection fraction <35% (nuclide). In addition to the following cases: acute myocardial infarction (duration <8 weeks), aortic valve or pulmonary valve stenosis, hypertrophic cardiomyopathy and exercise test time can not reach 1min. Judge according to the record and the observer’s statement of death