消化性溃疡患者血浆内皮素水平的临床观察

• 作 者: 胡乃中 刘功传 王刚石
• 机 构: 安徽医科大学第一附属医院
• 出 处: 安徽医科大学学报
• 发表日期: 1999年02期
• 关键词: 内皮缩血管肽类/血液 消化性溃疡/血液

目的观察消化性溃疡及溃疡并发出血患者血浆内皮素（ＥＴ）水平的变化。方法采用放射免疫法测定１３例胃溃疡、１７例十二指肠球部溃疡患者的血浆ＥＴ水平，并与１２例健康人对照。结果血浆ＥＴ水平（ｎｇ·Ｌ－１）：十二指肠球部溃疡组（８４１０６±６３４８９）、胃溃疡组（７３６６９±３６６１４）较对照组（３６１７５±８０５２）显著升高（Ｐ＜００１）。溃疡合并出血量＞５００ｍｌ组（９３８６７±６３９１９）与出血量＜５００ｍｌ组（６５３００±３５９２１）相比明显升高，差异有显著性（Ｐ＜００５）。溃疡直径≤１０ｃｍ组（７６２８３±５７４１２）与溃疡直径＞１０ｃｍ组（８２８００±３９６０７）相比差异无显著性（Ｐ＞００５）。结论ＥＴ可能是一个重要的致溃疡因子，尤其在溃疡合并出血量大时，血浆ＥＴ进一步升高。

Objective To observe the changes of plasma endothelin (ET) in patients with peptic ulcer and ulcer complicated by hemorrhage. Methods The levels of plasma ET in 13 patients with gastric ulcer and 17 patients with duodenal ulcer were measured by radioimmunoassay and compared with 12 healthy controls. Results Plasma ET level (ng · L-1) was significantly higher in the duodenal ulcer group (84106 ± 63489) and gastric ulcer group (73669 ± 36614) than in the control group (36175 ± 8052) was significantly higher (P <001). The ulcer combined hemorrhage> 500ml group (93867 ± 63919) was significantly higher than the hemorrhage <500ml group (65300 ± 35921), the difference was significant (P <005). There was no significant difference in ulcer diameter≤10cm (76283 ± 57412) and ulcer diameter≥10cm (82800 ± 39607) (P> 005). Conclusions ET may be an important cause of ulceration, especially in patients with large ulcer bleeding, the plasma ET increased further.