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目的 观察慢性肾功能不全病人及血液透析前后血浆中TNFα和sTNFαR水平的变化及两者的相关性。方法 采用ELISA方法检测慢性肾功能不全病人及血液透析前后血浆中TNFα和sTNFαR水平 ,并以正常人作为对照。结果 慢性肾功能不全尿毒症期和血液透析患者血浆TNFα水平较对照组明显升高。肾功能不全各期sTNFαR含量均显著高于正常对照组。慢性肾功能不全患者血浆TNFα和sTNFαR与尿素氮有明显相关性 ;TNFα与sTNFαR之间也存在正相关。血透后TNFα含量较血透前明显增加 ,sTNFαR水平较透析前虽有增加趋势 ,但没有统计学意义。结论 TNFα和sTNFαR在慢性肾功能不全各期及血液透析前后的变化可作为观察肾脏疾病发展的重要指标
Objective To investigate the changes of plasma TNFα and sTNFαR levels in patients with chronic renal failure and before and after hemodialysis, and their relationship. Methods The plasma levels of TNFα and sTNFαR in patients with chronic renal failure and before and after hemodialysis were detected by ELISA, and normal controls were used as controls. Results Chronic renal insufficiency in patients with uremia and hemodialysis plasma TNFα levels were significantly higher than the control group. The levels of sTNFαR in each stage of renal dysfunction were significantly higher than those in normal control group. Plasma TNFα and sTNFαR in patients with chronic renal insufficiency were significantly correlated with urea nitrogen; there was also a positive correlation between TNFα and sTNFαR. After hemodialysis TNFα content than before hemodialysis was significantly increased, sTNFαR levels than before dialysis although there is an increasing trend, but not statistically significant. Conclusion The changes of TNFα and sTNFαR at different stages of chronic renal failure and before and after hemodialysis can be used as an important index to observe the development of kidney disease