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目的观察严格饮食干预对糖尿病患者血脂和超敏C反应蛋白的影响。方法招募2型糖尿病患者106例,经过筛选,随机分为2个组,即膳食干预治疗组(WP组)71例和常规治疗对照组(UC组)35例。患者在进行标准的糖尿病临床管理的基础上,对常规治疗对照组患者进行糖尿病饮食健康指导,膳食干预治疗组患者进行严格膳食干预。治疗前与治疗3个月后,分别观察患者糖化白红蛋白、血脂和超敏C反应蛋白(hs-CRP)水平。结果膳食干预治疗组治疗后糖化血红蛋白、hs-CRP、总胆固醇、低密度脂蛋白胆固醇较治疗前明显降低(P<0.05);其下降幅度与对照组比较,差异有统计学意义(P<0.05)。结论严格饮食干预可显著降低糖化血红蛋白水平、hs-CRP、总胆固醇及低密度脂蛋白胆固醇,对心血管系统具有保护作用。
Objective To observe the effect of strict diet intervention on serum lipids and high-sensitivity C-reactive protein in diabetic patients. Methods A total of 106 patients with type 2 diabetes were enrolled. After screening, they were randomly divided into two groups: 71 patients in the diet intervention group (WP group) and 35 patients in the conventional therapy group (UC group). On the basis of the standard clinical management of diabetes, patients underwent routine dietary interventions in the control group and patients undergoing dietary interventions. Patients with glycosylated hemoglobin, lipids and hs-CRP levels were observed before treatment and after 3 months of treatment. Results After treatment, the levels of HbA1c, hs-CRP, total cholesterol and low density lipoprotein cholesterol in the intervention group were significantly lower than those before treatment (P <0.05), and the difference was significant compared with the control group (P <0.05 ). Conclusions Strict dietary intervention can significantly reduce the levels of HbAlc, hs-CRP, total cholesterol and low-density lipoprotein cholesterol, and has a protective effect on cardiovascular system.