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最近曾报告一种新的临床综合征即由于循环胰 岛素结构异常所致的家族性高胰岛素血症,它的特征是多见于轻型糖尿病、缺乏胰岛素抵抗以及免疫效应的胰岛素浓度迅速升高而C肽水平正常(低C肽:胰岛素分子比率)。因患者有此综合征的病人对外源性胰岛素敏感,所以常见于典型的非胰岛素依赖型糖尿病(NIDDM),它以胰岛素抵抗为特征,似乎是糖尿病中的一种特殊类型。目前世界上已报导了六个家庭,表现胰岛素或前胰岛素结构异常的
Recently, a new clinical syndrome, familial hyperinsulinemia due to structural abnormalities of circulating insulin, has been reported. It is characterized by an increase in the concentration of C-peptide, which is more common in patients with mild diabetes, insulin resistance, and immune effects Normal level (low C-peptide: insulin molecule ratio). Because patients with this syndrome are exogenous insulin-sensitive, they are common in the classic non-insulin-dependent diabetes mellitus (NIDDM), which is characterized by insulin resistance and appears to be a specific type of diabetes. Currently, six families have been reported in the world to show structural abnormalities of insulin or proinsulin