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目的寻找一种非损伤性且能早期诊断ＳＬＥ并发狼疮性肾炎（ＬＮ）的指标。方法从肾组织中提取肾小球基底膜和肾小管上皮抗原，然后采用斑点ＥＬＩＳＡ（Ｄｏｔ－ＥＬＩＳＡ）法对５０例活动期ＳＬＥ患者血液中的肾小球基底膜抗体（ＧＢＭ－Ａｂ）及肾小管抗体（Ｔｕｂ－Ａｂ）进行检测。结果ＧＢＭ－Ａｂ检出阳性率达６８％，Ｔｕｂ－Ａｂ阳性率达７８％。与患者尿蛋白升高检出率（４８％）相比，两种抗肾抗体检出率均较高。此外，ＧＢＭ－Ａｂ或Ｔｕｂ－Ａｂ检测阳性的患者与临床诊断ＬＮ相符率达９２％。结论ＧＢＭ－Ａｂ或Ｔｕｂ－Ａｂ的检出可为临床早期诊断ＬＮ提供一定的依据。
Objective To find a non-invasive and early diagnosis of SLE complicated with lupus nephritis (LN). Methods The glomerular basement membrane and tubular epithelial antigens were extracted from renal tissue. Then 50 samples of glomerular basement membrane antigen (GBM-Ab) and renal Tubular antibody (Tub-Ab) for testing. Results The positive rate of GBM-Ab was 68% and the positive rate of Tub-Ab was 78%. The detection rate of both anti-renal antibodies was higher than that of patients with elevated urinary protein (48%). In addition, patients with a positive GBM-Ab or Tub-Ab test corresponded to 92% of clinically diagnosed LNs. Conclusion The detection of GBM-Ab or Tub-Ab can provide some evidences for early clinical diagnosis of LN.