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在人类与疾病的斗争历史上,天然来源的药物已为各类疾病的传统治疗提供了基础,同样也为恶性肿瘤(下皆称肿瘤)的化学治疗提供了有用的武器。通过对广泛而悠久的民间用药的总结,发现用于肿瘤治疗的天然产物(主要是植物)超过3000种。有组织有系统地研究天然产物以寻找抗肿瘤药还只有20余年的历史,但发展迅速,已有160000种以上的微生物发酵产物,200000种以上的植物提取物经历了不同的抗肿瘤活性评价,从中发现了一些具有显著抗肿瘤作用的物质,少数已推荐临床使用。动物产物的抗肿瘤活性评价始于七十年代初,至今还极少可用于临床。 20余年来,从天然产物中寻找抗肿瘤药的工作一
In the history of struggle between humans and diseases, natural sources of medicine have provided the basis for traditional treatments for various types of diseases, and they also provide useful weapons for the treatment of malignant tumors (hereinafter referred to as tumors). By summarizing a wide range of folk medicines, it has been discovered that more than 3,000 natural products (mainly plants) have been used for cancer treatment. It has been more than 20 years since systematically researching natural products to find anti-tumor drugs, but it has developed rapidly. There are more than 160,000 microbial fermentation products, and more than 200,000 plant extracts have undergone different anti-tumor activity evaluations. Some of them have been found to have significant anti-tumor effects, and a few have been recommended for clinical use. The evaluation of the anti-tumor activity of animal products began in the early 1970s and has rarely been used clinically. For more than 20 years, looking for antineoplastic agents from natural products