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目的 探讨性激素及其受体与膀胱癌的关系。方法 用放免法测定 2 9例膀胱癌患者手术前后的血清睾酮 (T)、雌二醇 (E2 )、孕酮 (P)、并测定 2 5例健康献血员的T、E2 、P作对照。同时用S P免疫组化法检测 2 8例膀胱癌组织、 2 0例癌旁组织及 2 1例正常膀胱组织的雄激素受体 (AR)、雌激素受体 (ER)和孕激素受体 (PR)结果 和对照组相比 ,膀胱癌患者的T和T E2 比值升高 ,E2 降低。手术后T和T E2 比值下降 ,E2 升高。膀胱癌组织的AR阳性率高于正常膀胱组织。结论 膀胱癌患者存在明显的性激素比例失调 ,高雄激素和低雌激素水平可能与膀胱癌的发病有关。手术后性激素比例趋于协调
Objective To investigate the relationship between sex hormones and their receptors and bladder cancer. Methods Serum testosterone (T), estradiol (E2) and progesterone (P) in 29 bladder cancer patients before and after operation were measured by radioimmunoassay. T, E2 and P in 25 healthy blood donors were measured. SP immunohistochemistry was used to detect the expressions of androgen receptor (AR), estrogen receptor (ER) and progesterone receptor (ER) in 28 cases of bladder cancer, 20 cases of paracancerous tissues and 21 cases of normal bladder tissues PR) Results Compared with the control group, patients with bladder cancer T and T E2 ratio increased, E2 decreased. After surgery, the ratio of T to T E2 decreased and E2 increased. The positive rate of bladder cancer was higher than that of normal bladder tissue. Conclusions There is a significant imbalance of sex hormones in bladder cancer patients. The levels of high androgen and low estrogen may be related to the pathogenesis of bladder cancer. The proportion of sex hormone after surgery tends to be coordinated