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目的从西蒙１号甘薯茎叶中提取不同部位，并筛选其抗肿瘤有效部位。方法用水及有机溶剂回流法，从西蒙１号甘薯茎叶中获得其水提取物（ＳＷ）、乙醇提取物（ＳＡ）、氯仿提取物（ＳＣ），以Ｋ５６２、ＥＡＣ、Ｈ２２等癌细胞株及Ｓ１８０、Ｕ１４荷瘤鼠进行体内外抗肿瘤活性筛选。结果ＳＷ、ＳＣ对Ｋ５６２、ＥＡＣ、Ｈ２２的ＩＣ５０为１７６．７～１６１６．６μｇ／ｍｌ，ＳＡ对Ｋ５６２、ＥＡＣ、Ｈ２２的ＩＣ５０分别为２３．８，６２．９，１０６．３μｇ／ｍｌ。ＳＡ２．４ｇ／ｋｇ口服１０ｄ，对Ｓ１８０、Ｕ１４荷瘤鼠的抑瘤率分别为４８．２％，５３．４％。结论西蒙１号甘薯茎叶有一定的体内外抗肿瘤活性，其乙醇提取物为抗肿瘤活性部位。
Objective To extract different parts from the stems and leaves of sweet potato (Simon 1) and screen its effective anti-tumor sites. Methods Water extracts (SW), ethanol extracts (SA) and chloroform extracts (SC) were obtained from the stems and leaves of Simon 1 sweet potato using water and organic solvent refluxing method. The cell lines K562, EAC, and H22 were used. S180 and U14 tumor bearing mice were screened for antitumor activity in vitro and in vivo. Results The IC50 of SW and SC against K562, EAC and H22 was 176.7-1616.6 μg/ml, and the IC50 of SA against K562, EAC and H22 were 23.8, 62.9 and 106.3 μg/ml, respectively. When SA2.4g/kg was orally administered for 10 days, the tumor inhibition rates of S180 and U14 tumor bearing mice were 48.2% and 53.4%, respectively. Conclusion The stem and leaf of sweet potato of Simon 1 had some anti-tumor activity in vitro and in vivo. Its ethanol extract was an anti-tumor active site.