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肿瘤坏死因子 (ＴＮＦ)是体内具有多种生物活性的细胞因子 ,并通过与其相应受体ＣＤ12 0ａ(ｐ5 5 )或ＣＤ12 0ｂ(ｐ75 )结合 ,发挥抗肿瘤、抗病毒感染的作用 ,诱发炎症反应以及刺激某些正常细胞的生长。ＴＮＦ基因与ＭＨＣ基因紧密连锁 ,编码ＴＮＦ的基因位于ＨＬＡ Ｂ以及ＨＬ
Tumor necrosis factor (TNF) is a cytokine that has many biological activities in vivo and exerts antitumor and antiviral infection by binding with its corresponding receptor CD12 0a (p5 5) or CD12 0b (p75), and induces inflammatory reaction As well as stimulate the growth of certain normal cells. The TNF gene is closely linked to the MHC gene, and the gene encoding TNF is located on HLA B and HL