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目的：评价放射性核素五价锝标记的二巯基丁二酸[~(99m)TC（V)-DMSA]则显像对甲状腺髓样癌（MTC）的临床价值。方法：43例各种甲状腺肿瘤术前患者、12例MTC术后拟进一步治疗的患者和8例MTC根治术后患者接受了1～3次~(99m)Tc（V）-DMSA显像研究。结果：~(99m)Tc（V）-DMSA能被MTC高度摄取，图像清晰，正常甲状腺组织及其它甲状腺良恶性肿瘤不摄取放射性，~(99m)Tc（V）-DMSA对MTC诊断灵敏度为81.8％（18/22），特异性为100%（41/41）,准确性为93.7％（59/63）。~(99m)Tc（V)-DMSA能特异性寻找术后残留或复发、转移灶，能发现小至1cm、B超和CT不易识别、临床难于扪及的MTC病灶，与血降钙素水平一起检测，可望早期发现亚临床病灶。结论：~(99m)Tc（V）-DMSA显像是MTC的一个特异性检查手段，对于MTC的诊断、定位、监测疗效和随访有重要的临床价值。
OBJECTIVE: To evaluate the clinical value of radionuclide-labeled dimercaptosuccinic acid [~(99m)TC(V)-DMSA] imaging for medullary thyroid carcinoma (MTC). METHODS: Forty-three patients with preoperative thyroid tumors, 12 patients undergoing MTC after further treatment, and 8 patients after MTC radical surgery received 1 to 3 99m Tc(V)-DMSA imaging studies. RESULTS: ~(99m)Tc(V)-DMSA was highly uptaken by MTC with clear images. Normal thyroid tissue and other benign and malignant thyroid tumors did not take up radioactivity. The diagnostic sensitivity of ~(99m)Tc(V)-DMSA to MTC was 81.8. % (18/22), specificity was 100% (41/41), and accuracy was 93.7% (59/63). ~(99m)Tc(V)-DMSA can specifically find postoperative residual or recurrence, metastases, and can detect MTC lesions as small as 1cm, B-ultrasonography, CT scan and clinically difficult to treat, and serum calcitonin levels. With detection, subclinical lesions can be detected early. Conclusion: ~(99m)Tc(V)-DMSA imaging is a specific examination method for MTC. It has important clinical value for the diagnosis, localization, monitoring efficacy and follow-up of MTC.