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Licata等用高张盐水合并应用大量速尿治疗严重心衰患者,获得较好的疗效。 该治疗方案是非常规的,如何解释其研究结果?有两种相对立的观点,一种认为Licata等研究的结果可能是无效的,因为参加例数较少,缺乏双盲对照,可能导致结果偏倚。其次,静脉速尿应用超剂量(500～1000mg,每日二次)可导致肾脏功能损害、低血压。而支持观点认为:未接受高张盐水组血肌酐、血尿素氮明显增加,如果高张盐水
Licata and other high-speed saline combined with a large number of furosemide treatment of patients with severe heart failure, access to better efficacy. The treatment regimen is unconventional. How do you interpret the findings? There are two opposing views. One is that the results of Licata et al. May not be valid because of the low number of participants and the lack of double-blind controls that could lead to bias in outcomes . Second, the application of intravenous furosemide overdose (500 ~ 1000mg, twice daily) can lead to renal dysfunction, hypotension. The support point of view that: did not accept the serum creatinine in hypertensive saline group, blood urea nitrogen increased significantly if the high-salt water