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与碳链聚合物相比,聚氨基酸类高分子由于其生物相容性好、可降解代谢、毒副作用低等优点而被广泛应用于生物医药领域。基于天冬氨酸的聚天冬酰胺衍生物,其合成方法简单多样,通过对其修饰改性可制备出具有各种环境响应性(温度、p H和还原敏感)的智能高分子,得到高效、低毒的药物/基因载体,实现可控释放、增强疗效、降低药物副作用的目的。本文重点介绍了聚天冬酰胺衍生物(特别是刺激响应性聚天冬酰胺衍生物)的合成改性方法、及其在药物和基因载体领域最新的研究进展,并对其发展前景进行了展望。
Compared with carbon chain polymers, polyamino acid polymers are widely used in the field of biomedicine because of their good biocompatibility, biodegradability, low toxicity and side effects. Aspartic acid-based polyaspartamide derivatives are simple and diverse in their synthesis methods. By modifying and modifying them, smart polymers with various environmental responsiveness (temperature, pH, and reduction sensitivity) can be prepared and highly effective , Low toxicity of drug / gene carrier, to achieve controlled release, enhance efficacy, reduce drug side effects. This review focuses on the synthesis and modification of polyaspartamide derivatives (especially stimulatory responsive polyaspartamide derivatives) and their recent advances in the field of pharmaceuticals and gene vectors and their prospects for future development .