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[目的]研究瘦素在评价卵巢功能衰竭倾向中的价值及其意义。[方法]采用放射免疫分析法测定252例研究组及223例对照组的血清瘦素,比较两组间差异;再将研究组根据月经紊乱特点分为A组161例,B组91例,比较各种月经紊乱类型血清瘦素水平及性激素水平及卵巢和子宫体积的变化。[结果]研究组与对照组比较,血清瘦素浓度显著升高(P﹤0.01);研究组血清雌二醇水平增高(P﹤0.01),而血清卵泡刺激素差异无统计学意义;研究组卵巢和子宫体积与对照组比较差异有统计学意义(P﹤0.01)。[结论]瘦素与卵巢功能低下密切相关,但瘦素作为预测卵巢功能衰竭倾向的更早期指标,尚需进一步探讨。
[Objective] To study the value and significance of leptin in evaluating the tendency of ovarian failure. [Methods] Serum leptin was determined by radioimmunoassay in 252 cases of study group and 223 cases of control group, and the differences between the two groups were compared. According to the characteristics of menstrual disorders, the study group was divided into 161 cases in group A and 91 cases in group B Serum levels of leptin and sex hormones and ovarian and uterine volume in various menstrual disorders. [Results] Compared with the control group, the concentration of serum leptin in the study group was significantly increased (P <0.01); the level of serum estradiol was increased in the study group (P <0.01), but there was no significant difference in the serum follicle stimulating hormone Ovarian and uterine volume compared with the control group, the difference was statistically significant (P <0.01). [Conclusion] Leptin is closely related to ovarian dysfunction. However, as an earlier indicator of ovarian failure, leptin needs to be further explored.