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目的:以1例去势抵抗性前列腺癌(CRPC)患者的治疗为例,阐述循证实践的具体步骤和内容。方法:针对患者病情提出临床问题,系统检索Pub Med、EMBASE、Cochrane Library、Clinical Trial Registries等数据库,检索时限截至2014年12月,查找相关的研究证据,并对证据进行质量评价及应用。结果:患者病情得到缓解,治疗有效。结论:开展循证实践需要结合患者病情、研究证据和患者意愿,并遵循一定的步骤。
Objective: To illustrate the specific steps and contents of evidence-based practice in one case of treatment of castrated resistant prostate cancer (CRPC). Methods: According to the patient’s condition, clinical problems were searched. PubMed, EMBASE, Cochrane Library, Clinical Trial Registries and other databases were searched systematically. The search period was up to December 2014, and the relevant research evidences were searched. The quality of the evidence was evaluated and applied. Results: The patient’s condition was relieved and the treatment was effective. CONCLUSIONS: Evidence-based practice requires a combination of patient condition, research evidence and patient willingness and follows certain steps.