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目的:研究老年高血压患者尿微量蛋白、内皮素(ET)、C反应蛋白(CRP)的水平变化,为观察早期老年高血压患者靶器官损害探索道路。方法:将130例老年原发性高血压患者根据血压水平分为3组,40例血压正常者为对照组,所有研究对象入选时血尿素氮、肌酐和24h尿蛋白总量均在正常范围内。取晨尿用免疫散射法测定尿白蛋白(Alb)、α1-微球蛋白(α1-MG)、β2微球蛋白(β2-MG),空腹血测定ET、CRP。结果:随着血压升高,各项尿微量蛋白指标及ET、CRP均有增高趋势。结论:尿微量蛋白、ET、CRP均可作为高血压靶器官损害的监测指标,其中内皮素在高血压的早期靶器官损害中更有检测意义。结论:有必要对基层医院及非药学的医务人员进行长期的ADR专业知识的宣传和培训,以提高医务人员对ADR知识的整体认知水平。
Objective: To study the changes of urinary microalbumin, endothelin (ET) and C-reactive protein (CRP) levels in elderly patients with hypertension to explore the target organ damage in early-stage elderly hypertensive patients. Methods: 130 elderly patients with essential hypertension were divided into three groups according to their blood pressure levels and 40 patients with normal blood pressure as the control group. The blood urea nitrogen, creatinine and 24-hour urine protein were all within the normal range when all subjects were enrolled . Urine albumin (Alb), α1-microglobulin (α1-MG), β2 microglobulin (β2-MG) and ET and CRP in fasting blood were measured by morning urine. Results: With the increase of blood pressure, the indexes of urinary microalbuminuria, ET and CRP increased. Conclusion: Urine microalbumin, ET and CRP can both be used as indicators of target organ damage in hypertension, and endothelin is more useful in early target organ damage of hypertension. Conclusion: It is necessary to conduct long-term ADR professional knowledge publicity and training for primary hospital and non-pharmacy medical staff so as to enhance the general cognition of medical staff to ADR knowledge.