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目的：检测中药四藤方对人胃癌细胞株BGC823细胞上皮钙黏附蛋白(E-cadherin)蛋白表达,并观察中药对胃癌细胞侵袭力的影响。方法实验组加入四藤方对细胞进行预处理,然后在进行培养。通过甲基噻唑基四唑法(MTT)检测细胞活性,使用划痕实验检测细胞侵袭能力变化,RT-PCR、检测E-cadherin mRNA表达的变化。结果四藤方能抑制人胃癌BGC823细胞的增殖；抑制缺胃癌细胞的侵袭力,并且能降低E-cadherin mRNA的表达。结论四藤方可抑制人胃癌BGC823细胞的增殖,可能通过降低E-cadherin mRNA的表达来抑制人胃癌BGC823细胞侵袭力。“,”Objective To test the traditional Chinese medicine on the four cane party people gastric cancer cell line BGC823 calcium epithelial cell adhesion protein-cadherin (E) protein expression, and to observe the influence of traditional Chinese medicine on gastric cancer cell invasion force. Methods The experimental group to join four cane party for preprocessing of cell and then in the training.By methyl thiazolyl tetrazolium method (determined by MTT) detection of cell activity, scratch experiments were used to detect cell invasion ability change, RT - PCR, E - cadherin mRNA expression changes.Results There were four cane can inhibit gastric cancer BGC823 cell proliferation;Lack of gastric cancer cell invasion force, and can reduce the E - cadherin mRNA expression.Conclusion Four cane can inhibit gastric cancer BGC823 cell proliferation, may by lowering E -cadherin mRNA expression to inhibition of human gastric cancer BGC823 cells aggressivity.