Plasmid DNA encoding neutralizing human monoclonal antibody without enhancing activity protects agai

• 作 者: Surachet Benjathummarak Atsushi Yamanaka Thanyaluk Krasae Chonlatip Pipattanaboon Subenya Injampa Pannamthip Pitaksajjakul Pongrama Ramasoota
• 机 构: DepartmentofSocialandEnvironmentalMedicine,CenterofExcellenceforAntibodyResearch（CEAR）,Mahidol-Osaka
• 出 处: 亚太热带医药杂志:英文版
• 发表日期: 2021年7期
• 关键词: Dengue virus LALA mutation Antibodydependent enhancement(ADE) Antibody plasmid E
• 基金项目: supported by the Faculty of Tropical Medicine,Mahidol University,Thailand,Research Fund through a Research and Researcher for Industry(RRi,Grant Number PHD59I0063 for SB),TRF Grant for New Researcher(

Objective: To evaluate the expression of DNA plasmid-harboring modified antibody gene that produces neutralizing human monoclonal antibodies against four serotypes of dengue virus(DENV) without enhancing activity in BALB/c mice. Methods: We constructed pF