【摘 要】
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BACKGROUND AND OBJECTIVEOsteoarthritis (OA) is a major cause of musculoskeletal pain and disability worldwide. Most treatment focuses on reducing symptoms, rather than modifying the disease process it
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BACKGROUND AND OBJECTIVEOsteoarthritis (OA) is a major cause of musculoskeletal pain and disability worldwide. Most treatment focuses on reducing symptoms, rather than modifying the disease process itself. This systematic literature review was designed to better understand the evidence for the routine use of agents to modify the progression of the OA disease process.
METHODSAn initial literature search identified 12 treatment agents, each recognized as possessing potential chondroprotective properties of the joint. The authors then identified randomized, controlled trials with a minimum of 12 months' follow-up, evaluating the efficacy of each of those agents. Measures included joint space width, distance between the femoral condyle and the tibial plateau and joint space narrowing or changes in cartilage volume. Of the articles reviewed, 13 fulfilled the criteria.
RESULTSThe data revealed that the long-term use of both oral glucosamine and chondroitin sulfate may have a small, but significant, effect on slowing disease progression in patients with OA of the knee. No conclusions were possible for treatment using intra-articular injections of these agents. Oral vitamins, including D and E, as well as nonsteroidal anti-inflammatory drugs, did not significantly affect the progression of the joint disease.
CONCLUSIONThis literature review supports the use of both oral glucosamine and chondroitin sulfate as structure modifying, chondroprotective drugs in patients with osteoarthritis of the knee.
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