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[目的]探讨超重环境下微波辐射大鼠的损伤情况。[方法]大鼠随机分为正常对照组、微波组和超重微波组,每组各12只。超重微波组先在6G超重环境下持续5 min后,接着在6G超重环境下实施200 m W/cm2的微波辐射5 min。[结果]超重微波组与正常对照组、微波组血清一氧化氮(NO)差异均有统计学意义(P<0.05);超重微波组、微波组的超氧阴离子、一氧化氮合酶(NO synthetase,NOS)与正常对照组比较,差异均有统计学意义(q1=13.587 6,q2=25.923 5;P<0.05);微波组与超重微波组超氧阴离子比较,差异有统计学意义(q=11.487 6,P<0.05);微波组过氧化氢酶(catalase,CAT)与正常对照组、超重微波组比较,差异有统计学意义(q1=7.840 4,q2=5.339 1;P<0.05);微波组谷胱甘肽过氧化物酶(glutathione peroxidase,GSH-pox)与正常对照组比较,差异有统计学意义(q1=5.900 1,P<0.05);超重微波组、微波组GSH与正常对照组比较,差异有统计学意义(q1=8.948 7,q2=7.114 5;P<0.05)。在肝组织匀浆中,超重微波组、微波组CAT与正常对照组比较,差异有统计学意义(q1=3.381 5,q2=2.970 9;P<0.05);超重微波组、微波组GSH-pox与正常对照组比较,差异有统计学意义(q1=3.382 2,q2=5.196 8;P<0.05);超重微波组NOS与微波组、正常对照组比较,差异有统计学意义(q1=4.239 3,q2=4.088 3;P<0.05);微波组GSH与正常对照组、超重微波组比较,差异有统计学意义(q1=11.663 4,q2=15.983 1;P<0.05)。显微镜下观察超重微波组的肝细胞轻度肿胀,间隙加大,肝血窦变宽。[结论]超重环境下微波辐射导致的损伤可能是超氧阴离子增高所致。
[Objective] To investigate the damage of rats under microwave radiation in overweight environment. [Methods] The rats were randomly divided into normal control group, microwave group and overweight microwave group, 12 rats in each group. The overweight microwave group was first exposed to 6G overweight environment for 5 min and then subjected to 200 mW / cm2 microwave irradiation over 6G overweight environment for 5 min. [Results] The levels of serum nitric oxide (NO) in microwave group and microwave group were significantly different (P <0.05). The levels of superoxide anion, nitric oxide synthase (NO) (q1 = 13.587 6, q2 = 25.923 5; P <0.05). There was a significant difference in the superoxide anion between the microwave group and the overweight microwave group (q = 11.487 6, P <0.05). Compared with normal control group and overweight microwave group, catalase (CAT) in microwave group showed significant difference (q1 = 7.840 4, q2 = 5.339 1; ; GSH-pox in microwave group was significantly different from that in normal control group (q1 = 5.900 1, P <0.05); GSH-overexpression in microwave group and microwave group was significantly higher than that in normal group The difference between the two groups was statistically significant (q1 = 8.948 7, q2 = 7.114 5; P <0.05). In the liver tissue homogenate, CAT in microwave group and microwave group were significantly different from those in normal control group (q1 = 3.381 5, q2 = 2.970 9; P <0.05); in overweight microwave group and microwave group, GSH-pox Compared with normal control group, the difference was statistically significant (q1 = 3.382 2, q2 = 5.196 8; P <0.05); there was significant difference between NOS group and normal control group in overweight microwave group (q1 = 4.2393 (q1 = 11.663 4, q2 = 15.983 1; P <0.05). Compared with normal control group and overweight microwave group, the GSH of microwave group was statistically significant (q1 = 11.663 4, q2 = 15.983 1; Under the microscope, the hepatocytes in the overweight microwave group were slightly swollen, the gap increased, and the hepatic sinusoid widened. [Conclusion] The damage caused by microwave radiation in overweight environment may be caused by the increase of superoxide anion.