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利用壳聚糖-甘油-饱和硼砂溶液为主要材料构建一种用于关节腔注射、具有缓释作用的壳聚糖反相温敏水凝胶系统,并对其理化性质和生物相容性进行初步研究。以凝胶的形成和胶凝时间为指标,考察壳聚糖浓度、壳聚糖与甘油的比例、pH值等因素对水凝胶理化性质的影响,并对其体外释放行为、流变学、生物相容性等特性进行表征。温敏凝胶在常温下为溶胶态,当处于37℃时转变为凝胶态,并具有一定的缓释效果,生物相容性较高。
A chitosan reverse-phase temperature-sensitive hydrogel system for intra-articular injection and sustained release was constructed by using chitosan-glycerol-saturated borax solution as the main material, and its physicochemical properties and biocompatibility were studied . Gel formation and gelation time were taken as indexes to investigate the effects of chitosan concentration, the ratio of chitosan and glycerol, pH and other factors on the physico-chemical properties of hydrogels. The release behavior, rheology, Biocompatibility and other characteristics of the characterization. Temperature-sensitive gel is sol state at room temperature, when in 37 ℃ into gel state, and has a sustained release effect, high biocompatibility.