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抗心律失常的药物从临床和心律失常的分类讲可分为抗快速心律失常药物和抗缓慢心律失常药物。抗快速心律失常药物近代又按细胞电生理作用分为Ⅰ至Ⅱ类(即Amsdorf的六类分类法),分为:第Ⅰ类,抑制钠离子通透性为主的膜抑制性药物,以奎尼丁和普鲁卡因酰胺为代表,也包括N—乙酰普鲁卡因酰胺、双异丙吡胺、安他唑啉、心律平、常咯啉、缓脉灵、茚丙胺、美卡胺、氟卡胺、氯卡胺等;第Ⅱ类,缩短动作电位和QT间期的膜抑制性药物,以利多卡因和苯妥英钠为代表,也包括慢心律、室安卡因、氨甲酰苯唑(卡马西平);第Ⅲ类,β阻滞剂。以心得安为代表的各种β阻滞剂;第Ⅳ类,延长动作电位间期和阻断交感神经节后纤维药物,以乙胺碘呋酮和溴苄胺为代表,也包括硫酸苄甲胍和β阻滞剂中的甲磺胺心啶;第Ⅴ类,钙通道阻滞剂。以异搏定为代表,也包括心可定、硫氮唑酮、利多氟嗪等;第Ⅶ类,洋地黄类药物。另Vaughan Williams又将抗快速心律失常药物分为四类(即VW改进分类法):Ⅰ类为抑制钠离子内流药物,又分为Ia类,以奎尼丁和普鲁卡因酰胺为代表,有延长动作电位和QT间期的作用;Ib类,以利多卡因和苯英妥钠为代表,有缩短动作电位和QT间期的作用;Ic类,以英卡胺和氟胺卡为代表,无影响动作电位和QT间期的作用。近年来对此类药物的应用积累了不少经验、临床研究较广泛。Ⅰ类为β阻滞剂。Ⅱ类为延长动作电位间期和阻断交感神经节后纤维制剂,以乙胺碘呋酮和溴苄胺为代表。Ⅶ类为钙通道阻滞剂。VW改进分类法不包括强心甙,与Amsdorf的分类略有不同。
Anti-arrhythmic drugs from the classification of clinical and arrhythmia can be divided into anti-tachyarrhythmia drugs and anti-arrhythmia drugs. Anti-tachyarrhythmia drugs in recent times, according to the role of cell electrophysiology is divided into Ⅰ to Ⅱ (Amsdorf six categories), divided into: Class Ⅰ, inhibition of sodium ion permeability-based membrane inhibitory drugs to Quinidine and procainamide, as well as N-acetyl-procaine, disopyramide, antipyrine, cardiac rhythm, statin, Amine, flecainide, procaine, etc .; Class II, shortening the action potential and QT interval membrane inhibitory drugs to lidocaine and phenytoin as the representative, including slow heart rate, intraventricular Ancaine, ammonia armor Oxybenzazole (carbamazepine); Class III, beta blockers. The various types of beta blockers represented by propranolol; Class IV, extending the action potential interval and blocking the sympathetic postganglionic fibrosis drugs, represented by amiodarone and bromobenzyl amine, including benzyl Guanidine and beta-blockers mesylate; Class V, calcium channel blockers. To verapamil as the representative, but also including the heart can be set, dithiadiazolidin, such as doxorubicine; class Ⅶ, digitalis drugs. Another Vaughan Williams in turn the anti-tachyarrhythmia drugs are divided into four categories (ie VW improved classification): Ⅰ class to inhibit sodium influx of drugs, is divided into Ia class, quinidine and procainamide , There is an extension of the action potential and QT interval role; Ib class, with lidocaine and phenytoin as the representative, shortening the action potential and QT interval role; Ic class, Representative, without affecting the action potential and the role of QT interval. In recent years, the application of such drugs has accumulated a lot of experience, clinical research is more extensive. Ⅰ type of β blockers. Ⅱ class to extend the action potential interval and block the sympathetic ganglia after the fiber formulations, to amiodarone and bromobenzyl amine represented. Ⅶ class of calcium channel blockers. VW’s improved taxonomy does not include cardiac glycosides, slightly different from Amsdorf’s classification.