Steroidal saponins from the roots of Asparagus cochinchinensis

• 作 者: ZHU Guo-Lei HAO Qian LI Rong-Tao LI Hai-Zhou
• 机 构: Faculty of Life Science and Technology,Kunming University of Science and Technology,
• 出 处: Chinese Journal of Natural Medicines
• 发表日期: 2014年03期
• 关键词: Asparagus glucopyranosyl saponins methoxy roots silica elucidated Seven pyridine

AIM:To study the chemical constituents of the roots of Asparagus cochinchinensis(Asparagaceae).METHOD:The compounds were isolated with Diaion HP20,silica gel,and ODS chromatography,and their structures were determined on the basis of chemical methods,HR-ESI-MS,and 1D- and 2D-NMR techniques.RESULTS:Seven compounds were isolated from the n-butanol fraction of the roots of A.cochinchinensis,and their structures were elucidated as(25S)-26-O-β-D-glucopyranosyl-5β-furostan-3β,22α,26-triol-12-one-3-O-β-D-glucopyranoside(1),(25S)-26-O-β-D-glucopyranosyl-22α-methoxy-5β-furostan-3β,26-diol-12-one-3-O-β-D-glucopyranoside(2),(25S)-26-O-β-D-glucopyranosyl-5β-furostan-3β,22α,26-triol(3),(25S)-26-O-β-D-glucopyranosyl-5β-furstan-3β,22α,26-triol-3-O-β-D-glucopyranoside(4),(25S)-26-O-β-D-glucopyranosyl-5β-furostan-3β,22α,26-triol-3-O-α-L-rhamnopyranosyl-(1,4)-β-D-glucopyranoside(5),(25S)-5β-spirostan-3β-ol-3-O-α-L-rhamnopyranoside(6),and(25S)-5β-spirostan-3β-ol-3-O-β-D-glucopyranoside(7).CONCLUSION:Compounds 1 and 2 were two new furostanol saponins.

AIM: To study the chemical constituents of the roots of Asparagus cochinchinensis (Asparagaceae). METHOD: The compounds were isolated with Diaion HP20, silica gel, and ODS chromatography, and their structures were determined on the basis of chemical methods, HR-ESI- MS, and 1D- and 2D-NMR techniques. RESULTS: Seven compounds were isolated from the n-butanol fraction of the roots of A. cochinchinensis, and their structures were elucidated as (25S) -26-O-beta-D-glucopyranosyl -5β-furostan-3β, 22α, 26-triol-12-one-3-O- β -D- glucopyranoside (1), (25S) -26-O-β-D-glucopyranosyl- furostan-3β, 26-diol-12-one-3-O-β-D-glucopyranoside (2), (25S) -26-O-β-D-glucopyranosyl-5β-furostan-3β, 22α, 26-triol (25S) -26-O-β-D-glucopyranosyl-5β-furstan-3β, 22α, 26- triol-3-O-β-D-glucopyranoside -β-D-glucopyranosyl-5β-furostan-3β, 22α, 26-triol-3-O-α-L- rhamnopyranosyl- (1,4) spirostan-3β-ol-3-O-α-L-rhamnopyranoside (6), and (25S) -5β-spirostan-3β-ol-3-O- β-D-glu copyranoside (7) .CONCLUSION: Compounds 1 and 2 were two new furostanol saponins.