论文部分内容阅读
目的 探讨介入化疗后胰腺癌 β 连环素 (β catenin)表达的变化 ,并分析其临床意义。方法 2 0 0 0～2 0 0 2年通过对直接手术病人 (对照组 )和术前介入化疗的病人 (介入组 )各 2 3例的手术切除标本免疫组化染色 ,分析两组 β catenin异常表达率的差别。 结果 对照组 β catenin胞膜异常表达率为 69 6% ,介入组为 3 9 1% ,显著低于前者 (P <0 0 5) ;两组胞浆异常表达率的差异不显著。但介入组介入化疗后CT显示肿块缩小者胞浆异常表达率为 0 ,显著低于肿块无缩小者 (3 3 3 % ,P <0 0 5) ;且膜浆异常表达情况具有显著相关性。结论 β catenin胞膜异常表达会促进癌转移 ,介入化疗后异常表达减少提示可能会抑制转移 ;胞浆内异常表达会促进细胞增殖 ,介入化疗后肿块缩小者的异常表达显著下降 ,说明有抑制肿瘤细胞增殖的作用
Objective To investigate the changes of β catenin expression in pancreatic cancer after interventional chemotherapy and analyze its clinical significance. Methods From 2000 to 2002, 23 patients with direct surgery (control group) and 20 patients with preoperative interventional chemotherapy (intervention group), respectively, were examined by immunohistochemistry to analyze the abnormality of β catenin Differences in expression rates. Results The abnormal expression of β catenin in control group was 69.6%, and the intervention group was 391%, which was significantly lower than that in the former group (P <0.05). The difference between the two groups was not significant. However, after interventional chemotherapy, CT showed abnormal cytoplasmic expression of tumor mass in 0, significantly lower than that of tumor without mass reduction (333%, P <0 05), and abnormal expression of plasma membrane had a significant correlation. Conclusions The abnormal expression of β catenin cell membrane can promote the metastasis of carcinoma. The decreased expression of β catenin may inhibit the metastasis. Abnormal expression of intracellular cytoplasm can promote cell proliferation. The abnormal expression of β catenin membrane is significantly reduced after interventional chemotherapy. The role of cell proliferation