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目的:探讨不同性别人群发生不稳定型心绞痛(UAP)的相关危险因素。方法:选择本院住院部收治的138例UAP患者为UAP组及80例同期经冠状动脉造影检查冠脉正常的非CHD者为对照组进行研究,对不同性别UAP患者发病的相关因素进行分析和比较。结果:男性UAP组和男性对照组在吸烟、高血压病史、高密度脂蛋白胆固醇(HDL-C)、半胱氨酸(Hcy)、维生素B12(Vit B12)和叶酸(FA)方面存在显著性差异(P<0.05),两组其它指标比较无显著性差异(P>0.05);女性UAP组和女性对照组在高血压病史、糖尿病病史、尿酸(UA)、Hcy、VB12和FA方面存在显著性差异(P<0.05),两组其它指标比较无显著性差异(P>0.05)。Logistic回归分析显示:吸烟、高血压、HDL、Hcy、和Vit B12水平为男性UAP患者发病的独立危险因素(P<0.05~0.01);高血压、UA、Hcy、Vit B12和FA水平为女性UAP患者发病的独立危险因素(P<0.05)。结论:不同性别人群发生UAP的危险因素不同,血浆Hcy和UA水平为女性UAP的独立危险因素,而血浆Hcy水平为男性UAP的独立危险因素。
Objective: To investigate the risk factors of unstable angina pectoris (UAP) in different gender groups. Methods: A total of 138 patients with UAP treated in our inpatient department were selected as the UAP group and 80 patients with non-CHD who underwent coronary angiography during the same period were enrolled as control group. The related factors of onset of UAP in different sexes were analyzed and Compare Results: There were significant differences in smoking, history of hypertension, HDL-C, Hcy, Vit B12 and folic acid in male UAP group and male control group (P <0.05). There was no significant difference between the two groups (P> 0.05). There were significant differences in the history of hypertension, UA, Hcy, VB12 and FA between female UAP group and female control group (P <0.05). There was no significant difference between other two groups (P> 0.05). Logistic regression analysis showed that smoking, hypertension, HDL, Hcy, and Vit B12 levels were independent risk factors for the onset of UAP in men (P <0.05-0.01). The levels of hypertension, UA, Hcy, Vit B12 and FA were female UAP The incidence of patients with independent risk factors (P <0.05). CONCLUSION: The risk factors for UAP in different sexes are different. Plasma Hcy and UA levels are independent risk factors for female UAP. Plasma Hcy level is an independent risk factor for male UAP.