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目的 探讨Ｅｎｄｏｓｔａｔｉｎ 对高转移潜能肝癌ＬＣＩＤ２０ 生长的抑制作用。方法 ＬＣＩＤ２０ 组织植入裸鼠皮下，分别采用不同剂量的Ｅｎｄｏｓｔａｔｉｎ、顺铂以及二者联合治疗。每５ 天测量肿瘤的长短径。结果 ２ ｍｇ·ｋｇ－ １·ｄ－ １ 的Ｅｎｄｏｓｔａｔｉｎ 对肿瘤生长无作用，４ ｍｇ·ｋｇ－１·ｄ－ １ 的Ｅｎｄｏｓｔａｔｉｎ 和１ ｍｇ·ｋｇ－ １·ｄ－ １的顺铂对肿瘤生长有抑制作用，而联合用药组对肿瘤生长的抑制更强。结论 足量血管形成抑制剂可抑制肝癌生长；与细胞毒性药物联合应用可提高疗效。
Objective To investigate the inhibitory effect of endostatin on the growth of hepatocellular carcinoma LCID20 with high metastatic potential. Methods LCID20 tissue was implanted subcutaneously in nude mice. Different doses of endostatin, cisplatin and their combination were used. The length and length of the tumor are measured every 5 days. Results Endostatin 2 mg·kg-1 ·d-1 had no effect on tumor growth, 4 mg·kg-1·d-1 Endostatin and 1 mg·kg-1 ·d-1 cisplatin inhibited tumor growth. Effect, and the combination of drugs to inhibit the growth of tumors stronger. Conclusions A sufficient amount of angiogenesis inhibitor can inhibit the growth of liver cancer; combined application with cytotoxic drugs can improve the efficacy.