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切除雌鼠双侧卵巢以造成骨快速丢失作为模拟女性绝经后骨质疏松症的动物模型，从骨计量学、骨生物力学等方面综合观察单纯补充维生素Ｋ（９０ｍ ｇ／ｋｇ）、钙（５ｇ／ｋｇ）及两者联合作用６个月对骨丢失的影响。结果发现：与正常对照组（Ａ）大鼠相比，模型对照组（Ｂ）大鼠骨量显著减少，骨脆性增加。与模型对照组相比，单纯补充维生素Ｋ组（Ｄ） 股骨中点骨密度值显著提高，股骨干骺端及腰椎骨密度、股骨近侧端矿物质含量都有增高趋势，表明补充维生素Ｋ 可在一定程度上减少骨丢失；同时补充维生素Ｋ及钙组（Ｅ）股骨的最大挠度与最大应变值，与模型对照组相比也有增高趋势，表明补充维生素Ｋ可提高骨的柔韧性，改善股骨的力学性能。综合骨计量学与骨力学观察结果，发现各种实验措施对密质骨的效果皆优于松质骨，并且维生素Ｋ与钙的联合作用效果优于单纯补充维生素Ｋ 或钙。本实验结果提示：绝经后妇女，作为骨质疏松危险人群，增加膳食维生素Ｋ 与钙的摄入是有帮助的
The bilateral ovaries were excised to cause the rapid loss of bone. As an animal model to simulate female postmenopausal osteoporosis, the effects of simple vitamin K supplementation (90 m g / kg), calcium (5 g / Kg) and their combined effects on bone loss for 6 months. The results showed that: Compared with the normal control group (A) rats, the model control group (B) significantly reduced the amount of bone mass, increased bone fragility. Compared with the model control group, the bone mineral density at middle femur of vitamin K group (D) increased significantly, the femoral metaphyseal and lumbar spine BMD and proximal femur mineral content increased, indicating that vitamin K supplementation To a certain extent reduce bone loss; while vitamin K and calcium (E) femoral maximum deflection and maximum strain values, compared with the model control group also increased, indicating that vitamin K supplementation can improve the flexibility of the bone, improve the femur The mechanical properties. According to the results of bone metrology and bone mechanics, it is found that all kinds of experimental measures have better effects on cancellous bone than the cancellous bone, and the combined effect of vitamin K and calcium is better than that of vitamin K or calcium alone. Our results suggest that postmenopausal women, as risk groups for osteoporosis, may be helpful in increasing dietary intake of vitamin K and calcium.