【摘 要】
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A new phosphorylcholine, (6-hydroxy)hexyl-2-(trimethylammonio)ethyl phosphate (HTEP), was synthesized and characterized. Segmented polyurethane (SPU) containing
【机 构】
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Research Center on Surface and Interface Chemistry Engineering and Technology
论文部分内容阅读
A new phosphorylcholine, (6-hydroxy)hexyl-2-(trimethylammonio)ethyl phosphate (HTEP), was synthesized and characterized. Segmented polyurethane (SPU) containing phosphorylcholine structure was synthesized based on diphenylmethane diisocyanate (MDI), soft segment polytetramethylene glycol (PTMG) and HTEP, with 1,4-butanediol (BD)as a chain extender. The existence of phosphorylcholine structure on the surface of SPU was revealed by attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR), X-ray photoelectron spectroscopy (XPS) and water contact angle measurements. The blood compatibilities of the polymers were evaluated by hemolytic testing and a platelet-rich plasma (PRP) adhesion experiment, which was viewed by scanning electron microscopy (SEM) with polyurethane as a reference. The novel segmented polyurethane containing phosphorylcholine structure showed improved blood compatibility.
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