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目的：为探讨肝硬化患者生长激素（ＧＨ）的变化，对７８例肝炎后肝硬化患者进行临床观察。方法：采用放免法检测７８例肝硬化患者空腹血浆ＧＨ，６８例慢性胃炎患者作对照。肝硬化患者分２组，代偿组２６例，失代偿组５２例。１５例肝硬化患者同时进行葡萄糖耐量试验时ＧＨ变化检测。结果：对照组空腹ＧＨ平均值为１．２４±１．２４μｇ／Ｌ；肝硬化代偿组为２．７４±１．８５μｇ／Ｌ，其中ＧＨ＞５μｇ／Ｌ者４例（占１５．３８％）；失代偿组空腹ＧＨ均值为１２．１７±１１．１５μｇ／Ｌ，其中ＧＨ＞５μｇ／Ｌ者３７例（占７１．１５％）；后者明显高于前者及对照组（Ｐ＜０．０１）。１５例肝硬化患者服糖后ＧＨ呈反常性增高反应。结论：本研究结果显示肝硬化患者高ＧＨ血症与肝功能损害有一定关系。
Objective: To investigate the changes of growth hormone (GH) in patients with liver cirrhosis and to evaluate the clinical effect of 78 patients with posthepatitic cirrhosis. Methods: Radioimmunoassay was used to detect fasting plasma GH in 78 patients with cirrhosis and 68 chronic gastritis patients as controls. Patients with cirrhosis divided into 2 groups, compensatory group of 26 cases, decompensated group of 52 cases. Changes of GH in 15 patients with cirrhosis at the same time of glucose tolerance test. Results: In the control group, the average fasting GH was 1.24 ± 1.24μg / L and in the cirrhosis compensated group was 2.74 ± 1.85μg / L, in which 4 cases (15.38% ). The mean value of fasting GH in decompensated group was 12.17 ± 11.15μg / L, of which 37 cases (71.15%) were GH> 5μg / L; the latter was significantly higher than the former and the control group (P <0 .01). Fifteen cases of liver cirrhosis patients with abnormal GH increased GH response. Conclusion: The results of this study show that patients with cirrhosis of hyperlipidemia and liver dysfunction have a certain relationship.