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目的研究RON基因在人肺癌组织及正常肺组织中的表达水平及其临床意义。方法用免疫组化SP法检测80例肺癌患者的库存标本和20例同期手术切除的正常肺组织中RON的表达,RON基因表达与临床病理、预后之间的关系。结果RON基因在肺癌中表达的阳性率为53.75%(43/80),明显高于对照组正常肺组织的表达(0%)(P=0.000)。不同性别、年龄的患者和病理类型的肺癌组织中,RON基因的表达差异无显著性(P>0.05);RON基因表达的阳性率随TNM分期的升高而升高(I期29.03%、II期65.52%、III期75.00%)(P=0.002)。Kaplan-Meier生存分析显示RON阳性表达者的1、3及5年生存率(67.44%、20.93%和9.30%)明显低于阴性者(81.08%、45.94%和24.30%)(P=0.029)。结论RON基因可能在肺癌的发生、发展过程中起着重要作用,提示其可作为肺癌一种新的预后判断指标和治疗靶点。
Objective To study the expression and clinical significance of RON gene in human lung cancer tissues and normal lung tissues. Methods Immunohistochemical SP method was used to detect the expression of RON in 80 cases of lung cancer and 20 cases of normal lung tissue in the same period. The relationship between RON gene expression, clinical pathology and prognosis was studied. Results The positive rate of RON gene expression in lung cancer was 53.75% (43/80), which was significantly higher than that in normal lung tissue (0%) in the control group (P=0.000). There was no significant difference in the expression of RON gene between patients of different genders and ages and pathological types of lung cancer (P>0.05). The positive rate of RON gene expression increased with the increase of TNM stage (I 29.03%, I Period 65.52%, Phase III 75.00%) (P=0.002). Kaplan-Meier survival analysis showed that the 1-, 3-, and 5-year survival rates (67.44%, 20.93%, and 9.30%) of RON positive expression were significantly lower than those of the negative (81.08%, 45.94%, and 24.30%) (P=0.029). Conclusion The RON gene may play an important role in the occurrence and development of lung cancer, suggesting that it may serve as a new prognostic indicator and therapeutic target for lung cancer.