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中性粒细胞减少与甲氰咪胍有关,已有报道。多数病例骨髓显示粒细胞系统增生低下或成熟障碍,提示甲氰咪胍对有些病人粒系前躯细胞有毒性作用。作者通过体外骨髓培养研究甲氰咪胍对人类粒细胞生成的影响。骨髓由7例正常人和2例病人(与甲氰咪胍有关的中性粒细胞减少症并已恢复正常者)提供。正常成人骨髓培养后平均有69个集落形成。为了探索病人是否有抗体介入抑制粒细胞生成,故将正常人和病人骨髓细胞先用病人急性期血清,补体加或不加各
Neutropenia and cimetidine, has been reported. Most cases of bone marrow showed granulocyte system hyperplasia or maturation disorder, suggesting that cimetidine on some patients pre-myeloid cells toxic effect. The authors investigated the effect of cimetidine on human granulocyte formation in vitro by bone marrow culture. Bone marrow is provided by seven normal individuals and two patients (cimetidine-related neutropenia who have returned to normal). An average of 69 colonies formed after normal adult bone marrow culture. In order to explore whether the patient has antibodies involved in the inhibition of granulocyte production, so the normal and patient bone marrow cells with the patient first acute phase serum, complement with or without