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健康成年家兔18只,随机分为3组,分别静注吡喹酮溶液、吡喹酮纳米粒和吡喹酮长循环纳米粒(10 mg/kg)。以地西泮为内标,采用HPLC法测定家兔血浆中的吡喹酮。吡喹酮注射液和吡喹酮纳米粒的体内过程符合二房室模型,吡喹酮长循环纳米粒的体内过程符合三房室模型,3种制剂的主要药动学参数分别为:t1/2(1.27±1.56)、(1.13±0.66)和(23.82±8.94)h,CL(5.29±0.78)、(2.38±1.00)和(1.16±0.16)L.h-1.kg-1,AUC0→t(1.48±0.27)、(3.52±1.79)和(4.93±1.27)mg.h.ml-1,MRT(0.44±0.30)、(0.41±0.10)和(16.12±1.38)h。
Eighteen healthy adult rabbits were randomly divided into 3 groups: praziquantel solution, praziquantel nanoparticles and praziquantel long circulating nanoparticles (10 mg / kg) were injected intravenously. With diazepam as an internal standard, praziquantel in rabbit plasma was determined by HPLC. Praziquantel injection and praziquantel nanoparticles in vivo in line with the two-compartment model, praziquantel long circulating nanoparticles in vivo process in line with the three-compartment model, the three formulations of the main pharmacokinetic parameters were: t1 / 2 (1.27 ± 1.56), (1.13 ± 0.66) and (23.82 ± 8.94) h, CL (5.29 ± 0.78), 2.38 ± 1.00 and 1.16 ± 0.16 Lh-1.kg- ± 0.27), (3.52 ± 1.79) and (4.93 ± 1.27) mg.h.ml-1, MRT (0.44 ± 0.30), (0.41 ± 0.10) and (16.12 ± 1.38) h, respectively.