Predictive Value of Inflammation Biomarkers in Patients with Portal Vein Thrombosis

• 作 者: Jian-Bo Han Qing-Hua Shu Yu-Feng Zhang Yong-Xiang Yi
• 机 构: Department of Hepatopancreatobiliary Surgery,The Second Hospital of Nanjing,Nanjing University of Ch
• 出 处: 临床与转化肝病杂志（英文版）
• 发表日期: 2004年期
• 关键词: Inflammation biomarker Thrombosis Splenectomy Portal vein

Background and Aims: To investigate the usefulness of inflammation biomarkers to serve as a predictors of por-tal vein thrombosis (PVT) postoperatively (post) in patients with portal hypertension after splenectomy and periesoph-agogastric devascularization. Methods: A total of 177 liver cirrhosis patients were recruited from January 2013 to De-cember 2017. They were divided into a PVT group (n=71) and a non-PVT group (n=106), according to ultrasound ex-amination findings at 7-day post. Inflammation biomark-ers involving platelet-to-lymphocyte ratio (PLR), neutro-phil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), red blood cell distribution width-to-platelet ratio(RPR), mean platelet volume-to-platelet ratio (MPR) preoperatively (pre) and at 1, 3, 7-days post were record-ed. Results: The univariate logistic regression analysis in-dicated that PLR (pre) (odds ratio (OR)=3.963, 95％ con-fidence interval (CI)=2.070–7.587, p<0.000), MLR (pre) (OR=2.760, 95％ CI=1.386–5.497, p=0.004), PLR (post-day 7) (OR=3.345, 95％ CI=1.767–6.332, p=0.000) were significantly associated with the presence of PVT. The mul-tivariate logistic regression analysis results indicated that PLR (pre) (OR=3.037, 95％ CI=1.463–6.305, p=0.003), MLR (pre) (OR=2.188, 95％ CI=1.003–4.772, p=0.049), PLR(post-day 7) (OR=2.166, 95％ CI=1.053–4.454, p=0.036) were independent factors for predicting PVT. Conclusions: The PLR (pre), MLR (pre), and PLR (post-day 7) are predictors of portal vein thrombosis post in patients with portal hypertension after splenectomy and periesoph-agogastric devascularization.