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早在1929年Boveri已提出肿瘤与遗传有关系。他认为细胞异常分裂导致细胞遗传物质不均匀地传给子细胞,造成细胞内的变异,引起细胞癌变。以后陆续观察到许多种癌细胞显示染色体异常,有染色体畸变患者的肿瘤发生率较一般人为高,有些家族患癌的人数高于其他家族等现象,都支持肿瘤与遗传有关系的观点。但近年来,通过对肿瘤病因的深入研究和大量的肿瘤流行病学调查分析,显示癌的发生大多数是外因直接引起的。如河南林县为食管癌高发区,江苏启东为肝癌高发区,广东为鼻咽癌高发区等,原先认为可能与人群家族的遗传性有关,但后来发现
As early as 1929 Boveri has proposed the relationship between cancer and genetics. He believes that abnormal cell division leads to non-uniform distribution of cytogenetic material to daughter cells, resulting in intracellular variation, causing cancer cells. Since then, many kinds of cancer cells have been observed to display chromosomal abnormalities. The incidence of chromosomal aberrations in cancer patients is higher than that in other common people. Some families have more cancers than other families and support the view that tumors have genetic relationship. However, in recent years, through in-depth study of the etiology of the tumor and a large number of cancer epidemiological investigation and analysis, show that most of the occurrence of cancer is caused directly by external causes. Such as Henan Linxian high incidence of esophageal cancer, Jiangsu Qidong high incidence of liver cancer, high incidence of nasopharyngeal cancer in Guangdong, originally thought may be related to the herd of the crowd, but later discovered