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目的探讨同期放化疗联合辅助化疗治疗鼻咽癌患者的疗效及不良反应。方法选择2010年1月至2014年1月间收治的76例初治鼻咽癌患者,按照随机数字表法分为研究组和对照组,每组38例。对照组患者采用同期放化疗方案治疗,研究组患者应用同期放化疗联合辅助化疗治疗。观察两组患者的临床疗效以及化疗引起的不良反应。结果研究组患者的总有效率为73.7%,对照组为44.7%,研究组显著高于对照组,差异有统计学意义(P<0.05)。两组主要不良反应多数为Ⅰ~Ⅱ度,研究组脱发、口腔黏膜炎发生率显著高于对照组,差异有统计学意义(P<0.05),两组恶心、呕吐、腹泻、外周神经毒性、肝损伤发生率比较,差异无统计学意义(P>0.05)。结论同期放化疗联合辅助化疗治疗Ⅲ~Ⅳ期鼻咽癌患者可以显著提高临床疗效,但口腔黏膜炎和脱发的发生率较高,临床治疗应予以注意。
Objective To investigate the efficacy and adverse reactions of concurrent chemoradiotherapy combined with adjuvant chemotherapy in the treatment of patients with nasopharyngeal carcinoma. Methods From January 2010 to January 2014, 76 newly diagnosed nasopharyngeal carcinoma patients were divided into study group and control group according to the random number table method, with 38 cases in each group. Patients in the control group were treated with chemoradiotherapy during the same period. Patients in the study group were treated with concurrent chemoradiotherapy combined with adjuvant chemotherapy. To observe the clinical efficacy of two groups of patients and chemotherapy-induced adverse reactions. Results The total effective rate was 73.7% in the study group and 44.7% in the control group, which was significantly higher in the study group than in the control group (P <0.05). The main adverse reactions in both groups were grade Ⅰ ~ Ⅱ. The rate of hair loss and oral mucositis in the study group was significantly higher than that in the control group (P <0.05). The nausea, vomiting, diarrhea, peripheral neurotoxicity, The incidence of liver injury compared, the difference was not statistically significant (P> 0.05). Conclusion Radiotherapy combined with adjuvant chemotherapy in patients with stage Ⅲ ~ Ⅳ nasopharyngeal carcinoma can significantly improve the clinical efficacy, but the incidence of oral mucositis and alopecia higher, clinical treatment should be noted.