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目的 :探讨狼疮性肾炎患者活动期及缓解期尿液中丙氨酸氨基肽酶 (AAP)活性变化及其临床意义 ;方法 :采用改良Jung法分别测定了 30例正常对照组 ,1 6例活动期及 1 5例缓解期狼疮性肾炎患者尿AAP活性变化 ;结果 :正常对照组尿AAP活性为 9.8mu/mgCr±3.8mu/mgCr,狼疮性肾炎活动期组尿AAP活性为 6 6 .7mu/mgCr±2 4.6mu/mgCr,缓解期组尿AAP活性为 2 0 .3mu/mgCr± 6 .5mu/mgCr;活动期与对照组差异有显著性 (P <0 .0 5 ) ,缓解期与对照组差异无显著性 (P >0 .0 5 ) ,活动期与缓解期差异有显著性 (P <0 .0 5 ) ;结论 :观察尿液AAP活性变化有助于判断狼疮性肾炎的活动性和治疗效果
Objective: To investigate the changes and clinical significance of alanine aminopeptidase (AAP) in urine during active stage and remission stage in patients with lupus nephritis.Methods: 30 cases of normal control group and 16 cases of activity Urine AAP activity in patients with lupus nephritis in 15 cases of remission was measured. Results Urinary AAP activity in normal control group was 9.8mu / mgCr ± 3.8mu / mgCr, Urine AAP activity in active stage of lupus nephritis was 66.7mu / The activity of AAP in remission group was 20.3mu / mgCr ± 6.5mu / mgCr at the time of remission, and there was significant difference between active group and control group (P <0.05) There was no significant difference between the two groups (P> 0.05), and there was significant difference between active stage and remission stage (P <0.05). Conclusion: Observing the changes of urinary AAP activity is helpful to determine the activity of lupus nephritis And treatment effect