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目的:评价氧化钛纳米管对犬即刻种植骨结合效果的影响。方法:犬拔牙后即刻将光滑表面(对照组)和氧化钛纳米管表面(实验组)种植体植入拔牙窝内,于12周后处死取材,进行显微CT扫描、组织学染色分析以及生物力学检测。结果:扫描电镜显示经过阳极氧化后,钛表面形成了直径为30-80纳米的纳米管状结构;12周后,显微CT扫描结果提示实验组骨体积分数(BV/TV)、骨小梁数目(Tb.N)、骨小梁厚度(Tb.Th)均显著高于对照组,骨小梁间隙(Tb.Sp)显著低于对照组,差异具有统计学意义(P<0.05)。术后12周,实验组与对照组骨结合率分别为49.35±11.76%、31.79±13.07%,最大拔出力分别为105.28±27.87N、79.23±20.46N,实验组均显著高于对照组,差异均具有统计学意义(P<0.05)。结论:氧化钛纳米管表面有利于促进即刻种植后骨结合的效果。
OBJECTIVE: To evaluate the effect of titanium dioxide nanotubes on the effect of immediate bone implantation in dogs. Methods: Smooth tooth surface (control group) and titanium oxide nanotube surface (experimental group) implants were implanted into tooth extraction socket immediately after tooth extraction, and were sacrificed 12 weeks later. The samples were taken for microscopic CT scan, histological staining and biological Mechanical testing. Results: Scanning electron microscopy showed that nanotubes with a diameter of 30-80 nm were formed on the surface of titanium after anodic oxidation. After 12 weeks, the results of micro-CT scan showed that the BV / TV, the number of trabecular (Tb.N) and trabecular thickness (Tb.Th) were significantly higher than those in the control group. The Tb.Sp was significantly lower than that in the control group (P <0.05). At 12 weeks after operation, the bone-union rates of the experimental group and the control group were 49.35 ± 11.76% and 31.79 ± 13.07%, respectively, and the maximum pullout forces were 105.28 ± 27.87N and 79.23 ± 20.46N, respectively, significantly higher than those in the control group The differences were statistically significant (P <0.05). Conclusion: The surface of titanium dioxide nanotubes is helpful to promote the osseointegration effect after immediate implantation.