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三硝基甲苯(TNT)对人及实验大鼠都具有明显的致畸和致突变作用,但至今未见尿中代谢产物是否仍具诱变性的报道。由于尿致突变试验可作为评价环境与职业致癌物的生物学监测指标,因此对 TNT 染毒大鼠进行尿致突变研究,可为进一步探讨
Trinitrotoluene (TNT) has obvious teratogenic and mutagenic effects on human and experimental rats, but so far it has not been reported whether the metabolites in urine are still mutagenic. As the test of urinary mutagenicity can be used as a biological monitoring indicator to evaluate environmental and occupational carcinogens, it is of great value to study the mutagenesis of urine in TNT-exposed rats